Abstract

Overview of the Multifaceted Functions of lncRNA HOTAIR in Glioblastoma.

Author(s): Mohammed A Azab

Glioblastoma is an aggressive primary brain tumor. Recurrence is a major clinical problem. Several biological features favor recurrence of these tumors following surgery. Therapies to prolong survival are not completely effective. Non-coding genetic elements play a key role in the process of gliomagenesis. Non-coding RNAs are novel regulatory RNAs that play key roles in various processes as gene regulation, cell differentiation, and proliferation. Interestingly, some lncRNAs may act as tumor suppressors while others are oncogenic. In this review, we are going to illustrate the role of a well-known lncRNA HOX Transcript Antisense Intergenic RNA (HOTAIR) in glioma and highlight the possible functions in glioma.